✦ LIBER ✦

Natural killer cells in renal allograft rejection

✍ Scribed by Mr. G. Cooksey; R. A. Robins; R. W. Blamey

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 326 KB
Volume: 71
Category: Article
ISSN: 0007-1323
DOI: 10.1002/bjs.1800711124

No coin nor oath required. For personal study only.

✦ Synopsis

Monoclonal antibody Anti Leu 7 has been used to enumerate peripheral blood N K cells in

20 renal allograft recipients. Blood was taken preoperatively and three times per week for the first month a f e r transplantation; separated mononuclear cells were stained with Anti Leu 7 then analysed on a fluorescence activated cell sorter. Results were related to acute rejection episodes diagnosed clinically and confirmed by Trucut biopsy of grafs. A reduction in the number of Leu 7 positive cells occurred postoperatively. Nineteen out of 20 patients showed a rise in number of circulating N K cells during acute rejection episodes.

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