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Natural killer cell responses in renal transplant patients with cytomegalovirus infection

✍ Scribed by Heleen Venema; Arie P. Van Den Berg; Coba Van Zanten; Willem J. Van Son; Marijke Van Der Giessen; T. Hauw

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
462 KB
Volume
42
Category
Article
ISSN
0146-6615

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✦ Synopsis

Natural killer (NK) cell function in relation t o immunophenotypical signs of NK activation was studied prospectively in 15 renal transplant patients with cytomegalovirus (CMV) infection. NK activity (expressed as the percentage of K562 ly- sis) before onset of CMV infection reached a median of 6% (range 2-18%), comparable to values observed in noninfected controls [7% (range 7-21%). P < .I]. During CMV infection, NK activity rose to a maximum of 25% (6-6O%) (P < .001 vs. controls). Maximal values exceeded the upper level of controls in nine of 15 patients. NK activity was correlated to the number of CD56'HLADRf cells in the peripheral blood (r = .57, P < .001). These data suggest that NK cells play a role in the recovery from CMV infection in a substantial number of patients and that immunophenotypical analysis of NK activation provides a surrogate marker of NK cell function.

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