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Are “natural killer” cells involved in allograft rejection?

✍ Scribed by Arto Nemlander; Eero Saksela; Pekka Häyry

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
335 KB
Volume
13
Category
Article
ISSN
0014-2980

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✦ Synopsis

Natural killer" (NK) effector cells and large granular lymphocytes (LGL) are found inside rat renal allografts during rejection. Their appearance in situ precedes the appearance of cytotoxic T lymphocytes, and concomitantly with their influx in the allograft, the NK activity and the LGL are depleted from the recipient spleen. This suggests that the NK effector cells and the LGL are involved in allograft rejection, although their role(s) among the other in situ inflammatory effector pathways remains to be clarified.

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