The formation of reactive intermediates in the MAO-catalyzed oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
β Scribed by A.J. Trevor; N. Castagnoli; T.P. Singer
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 380 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0300-483X
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Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.
## Abstract Administration of the neurotoxicant 1βmethylβ4βphenylβ1,2,3,6βtetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. After MPTP lesioning in young adult mice, surviving nigrostriatal dopaminergi