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An electrochemical study of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its oxidation products

✍ Scribed by Clovis A. Linkous; Karen M. Schaich; Arthur Forman; Donald C. Borg


Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
964 KB
Volume
19
Category
Article
ISSN
1567-5394

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## Abstract Monoamine oxidase B metabolizes 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP; **1**) first to 1‐methyl‐4‐phenyl‐2,3‐dihydropyridinium salt (MPDP^+^; **5**), and then to 1‐methyl‐4‐phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5‐methyl analog **6** wa