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An electrochemical study of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its oxidation products

โœ Scribed by Clovis A. Linkous; Karen M. Schaich; Arthur Forman; Donald C. Borg


Publisher
Elsevier Science
Year
1988
Weight
802 KB
Volume
253
Category
Article
ISSN
0022-0728

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Conversion of 1-methyl-4-phenyl-1,2,3,6-
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## Abstract Monoamine oxidase B metabolizes 1โ€methylโ€4โ€phenylโ€1,2,3,6โ€tetrahydropyridine (MPTP; **1**) first to 1โ€methylโ€4โ€phenylโ€2,3โ€dihydropyridinium salt (MPDP^+^; **5**), and then to 1โ€methylโ€4โ€phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โ€methyl analog **6** wa