Conversion of 1-methyl-4-phenyl-1,2,3,6-
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Wieslaw Gessner; Arnold Brossi; Rong-Sen Shen; Richard R. Fritz; Creed W. Abell
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Article
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1984
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John Wiley and Sons
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German
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## Abstract Monoamine oxidase B metabolizes 1โmethylโ4โphenylโ1,2,3,6โtetrahydropyridine (MPTP; **1**) first to 1โmethylโ4โphenylโ2,3โdihydropyridinium salt (MPDP^+^; **5**), and then to 1โmethylโ4โphenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โmethyl analog **6** wa