Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to
โฆ LIBER โฆ
Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP)+, the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
โ Scribed by Thomas P. Singer; Rona R. Ramsay; K. McKeown; A. Trevor; N.E. Castagnoli Jr.
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 369 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Iron-mediated bioactivation of 1-methyl-
Iron-mediated bioactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in glial cultures
โ
Dr. Donato A. Di Monte; Hyman M. Schipper; Steven Hetts; J. William Langston
๐
Article
๐
1995
๐
John Wiley and Sons
๐
English
โ 492 KB
13C-labelling of N-methyl-4-phenyl-1,2,3
โ
C. H. Williams
๐
Article
๐
1989
๐
John Wiley and Sons
๐
French
โ 162 KB
Conversion of 1-methyl-4-phenyl-1,2,3,6-
โ
Wieslaw Gessner; Arnold Brossi; Rong-Sen Shen; Richard R. Fritz; Creed W. Abell
๐
Article
๐
1984
๐
John Wiley and Sons
๐
German
โ 383 KB
## Abstract Monoamine oxidase B metabolizes 1โmethylโ4โphenylโ1,2,3,6โtetrahydropyridine (MPTP; **1**) first to 1โmethylโ4โphenylโ2,3โdihydropyridinium salt (MPDP^+^; **5**), and then to 1โmethylโ4โphenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โmethyl analog **6** wa
Quantification of 1-methyl-4-phenyl-1,2,
โ
Ming-Chuen Shih; S. P. Markey
๐
Article
๐
1986
๐
John Wiley and Sons
๐
English
โ 436 KB
๐ 1 views
Neurotoxicity of 1-methyl-4-phenyl-1,2,3
โ
Dr. F. V. DeFeudis
๐
Article
๐
1988
๐
John Wiley and Sons
๐
English
โ 926 KB
Imuthiol prevents against the depression
โ
G. Renoux; M. Renoux; K. Biziere
๐
Article
๐
1988
๐
Elsevier Science
๐
English
โ 77 KB