๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP)+, the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

โœ Scribed by Thomas P. Singer; Rona R. Ramsay; K. McKeown; A. Trevor; N.E. Castagnoli Jr.


Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
369 KB
Volume
49
Category
Article
ISSN
0300-483X

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Iron-mediated bioactivation of 1-methyl-
โœ Dr. Donato A. Di Monte; Hyman M. Schipper; Steven Hetts; J. William Langston ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 492 KB

Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to

Conversion of 1-methyl-4-phenyl-1,2,3,6-
โœ Wieslaw Gessner; Arnold Brossi; Rong-Sen Shen; Richard R. Fritz; Creed W. Abell ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 383 KB

## Abstract Monoamine oxidase B metabolizes 1โ€methylโ€4โ€phenylโ€1,2,3,6โ€tetrahydropyridine (MPTP; **1**) first to 1โ€methylโ€4โ€phenylโ€2,3โ€dihydropyridinium salt (MPDP^+^; **5**), and then to 1โ€methylโ€4โ€phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โ€methyl analog **6** wa