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Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

✍ Scribed by T. Z. Aziz; D. Peggs; M. A. Sambrook; Dr. A. R. Crossman

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
549 KB
Volume
6
Category
Article
ISSN
0885-3185

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✦ Synopsis

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

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