✦ LIBER ✦

The expression of self antigenic determinants: implications for tolerance and autoimmunity

✍ Scribed by Mark J. Mamula; Joe Craft

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 706 KB
Volume: 6
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(94)90008-6

No coin nor oath required. For personal study only.

✦ Synopsis

T lymphocytes respond to small peptides in the context of major histocompatibility molecules and a host of other cell-surface proteins on antigen-presenting cells. By design, therefore, T-cell responses are dependent on the efficient and accurate processing of both foreign and self peptides by antigen-presenting cells. This review examines the functions of T ceils that may be specific for self peptides processed and presented under less than ideal conditions or outside the normal pathways of antigen processing. Do these T cells survive selection events and remain in the repertoire of normal lymphocytes? Moreover, can these cells become activated and are they important in the pathogenesis of autoimmunity?

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