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Post-translational modifications of self antigens: implications for autoimmunity

✍ Scribed by Stephen M Anderton

Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 123 KB
Volume: 16
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2004.09.001

No coin nor oath required. For personal study only.

✦ Synopsis

Alterations in amino acid sequence can generate neo-epitopes from self proteins, causing autoaggressive immune attack. There is a range of possible post-translational modifications (PTMs) of mammalian proteins that can allow immune recognition of neo-self epitopes. These effects can vary from overt increase in affinity of MHC or T-cell receptor binding, to more subtle effects on the activity of proteolytic enzymes involved in antigen processing. Furthermore, intriguing insights into how the complex interactions between inflammation, enzyme activity and protein modification can direct self recognition are beginning to be unearthed.

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