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Localization of self antigen: implications for antigen presentation and induction of tolerance

✍ Scribed by Brigitta Stockinger; Catriona F. Gran; Barbara Hausmann


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
737 KB
Volume
23
Category
Article
ISSN
0014-2980

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πŸ“œ SIMILAR VOLUMES


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## Abstract Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organ‐specific autoimmunity. This apparent paradox is in part explained by promiscuous expression of numerous tissue‐restricted self‐antigens (TRA) in medullary thymic epithelial cells (mTEC), wh

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Alterations in amino acid sequence can generate neo-epitopes from self proteins, causing autoaggressive immune attack. There is a range of possible post-translational modifications (PTMs) of mammalian proteins that can allow immune recognition of neo-self epitopes. These effects can vary from overt