Antigen receptor ‘capacity’ and the sensitivity of self-tolerance
✍ Scribed by David Nemazee
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 297 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0167-5699
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📜 SIMILAR VOLUMES
T lymphocytes respond to small peptides in the context of major histocompatibility molecules and a host of other cell-surface proteins on antigen-presenting cells. By design, therefore, T-cell responses are dependent on the efficient and accurate processing of both foreign and self peptides by antig
In this study we investigated the basis for immunity or tolerance to a mouse serum protein, the fifth component of complement (C5). In CS-deficient mice this protein is absent from serum and therefore they are not tolerized. Immunization of CS-deficient mice with C5-sufficient serum generates CD4' T