Systemic lupus erythematosus (SLE) is characterized by the production of high-titer IgG-class antinuclear antibodies (ANA). The principal targets of ANA in SLE include chromatin (DNA, histones, and other associated proteins) and ribonucleoproteins, such as small nuclear RNPs (snRNPs) that process pr
The recognition of self-antigens and autoimmune disease
β Scribed by Stacy C. Smith; Paul M. Allen
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 586 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
β¦ Synopsis
Recent studies have increased our understanding of the nature of autoimmune recognition and of the identity of autoantigens, at least in model systems. Knowledge of the autoantigens and the process of recognition is suggesting new therapies for autoimmune disease.
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