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Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

✍ Scribed by Douglas Hanahan

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
697 KB
Volume
10
Category
Article
ISSN
0952-7915

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✦ Synopsis

The thymus expresses many genes previously thought to be specific for cell types in other organs. Thus, insulin genes are expressed in rare cells of the thymic medulla. Thymus transplantation demonstrates a functional capability of such expression for self-tolerance induction. Correlative studies suggest that impaired thymic expression confers susceptibility to autoimmune disease.

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Highly variable expression of tissue-res
Highly variable expression of tissue-restricted self-antigens in human thymus: Implications for self-tolerance and autoimmunity
✍ Richard Taubert; Jochen Schwendemann; Bruno Kyewski 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB

## Abstract Induction of T cell tolerance in the thymus (central tolerance) is essential for preventing organ‐specific autoimmunity. This apparent paradox is in part explained by promiscuous expression of numerous tissue‐restricted self‐antigens (TRA) in medullary thymic epithelial cells (mTEC), wh