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The Discovery of N -((2 H -Tetrazol-5-yl)methyl)-4-(( R )-1-((5 r ,8 R )-8-( tert -butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

✍ Scribed by DeMong, Duane; Dai, Xing; Hwa, Joyce; Miller, Michael; Lin, Sue-Ing; Kang, Ling; Stamford, Andrew; Greenlee, William; Yu, Wensheng; Wong, Michael; Lavey, Brian; Kozlowski, Joseph; Zhou, Guowei; Yang, De-Yi; Patel, Bhuneshwari; Soriano, Aileen; Zhai, Ying; Sondey, Christopher; Zhang, Hongtao; Lachowicz, Jean; Grotz, Diane; Cox, Kathleen; Morrison, Richard; Andreani, Teresa; Cao, Yang; Liang, Mark; Meng, Tao; McNamara, Paul; Wong, Jesse; Bradley, Prudence; Feng, Kung-I; Belani, Jitendra; Chen, Ping; Dai, Peng; Gauuan, Jolicia; Lin, Peishan; Zhao, He


Book ID
126494353
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
529 KB
Volume
57
Category
Article
ISSN
0022-2623

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## Abstract 2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in ^14^C‐labelled form by using potassium[^14^C]‐cyanide. [^14^C](KT3‐