✦ LIBER ✦

Synthesis of [14C]KT3-671, 2-Propyl-8-oxo-1-[ (2′-(1H-[14C] tetrazole-5-yl) biphenyl-4-yl) methyl]-4,5,6, 7-tetrahydro-cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist

✍ Scribed by Naoto Ueyama; Takashi Yanagisawa; Tsuyoshi Tomiyama

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 263 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580361002

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✦ Synopsis

Abstract

2‐Propyl‐8‐oxo‐1‐[(2′‐(1H‐tetrazole‐5‐yl) biphenyl‐4‐yl)methyl]‐4, 5, 6, 7‐tetrahydrocyclohept imidazole (KT3‐671), which has been found to be a potent and selective angiotesin II receptor antagonist, was synthesized in ^14^C‐labelled form by using potassium[^14^C]‐cyanide. ^14^C 9 with a specific activity of 1.74GBq/mmol was prepared in four steps in 29.8% overall radio‐chemical yield from potassium[^14^C]‐cyanide.

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