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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

✍ Scribed by Hao, Junliang; Dehlinger, Veronique; Fivush, Adam M.; Rudyk, Helene C.E.; Britton, Thomas C.; Hollinshead, Sean P.; Vokits, Benjamin P.; Clark, Barry P.; Henry, Steven S.; Massey, Steven M.; Peng, Langu; Dressman, Bruce A.; Heinz, Beverly A.; Roberts, Edda F.; Bracey-Walker, Mallorie R.; Swanson, Steven; Catlow, John T.; Love, Patrick L.; Tepool, Anita D.; Peters, Steven C.; Simmons, Rosa Maria A.; Iyengar, Smriti; McKinzie, David L.; Monn, James A.

Book ID: 118739153
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 452 KB
Volume: 23
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2013.01.009

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