✦ LIBER ✦

Discovery of 2-Hydroxy- N , N -dimethyl-3-{2-[[( R )-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor Antagonist

✍ Scribed by Dwyer, Michael P.; Yu, Younong; Chao, Jianping; Aki, Cynthia; Chao, Jianhua; Biju, Purakkattle; Girijavallabhan, Viyyoor; Rindgen, Diane; Bond, Richard; Mayer-Ezel, Rosemary; Jakway, James; Hipkin, R. William; Fossetta, James; Gonsiorek, Waldemar; Bian, Hong; Fan, Xuedong; Terminelli, Carol; Fine, Jay; Lundell, Daniel; Merritt, J. Robert; Rokosz, Laura L.; Kaiser, Bernd; Li, Ge; Wang, Wei; Stauffer, Tara; Ozgur, Lynne; Baldwin, John; Taveras, Arthur G.

Book ID: 120363612
Publisher: American Chemical Society
Year: 2006
Tongue: English
Weight: 72 KB
Volume: 49
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0609622

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Biphenylsulfonamide Endothelin Receptor

Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N -[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]- N ,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ET A Selective Antagonist

✍ Murugesan, Natesan; Gu, Zhengxiang; Spergel, Steven; Young, Marian; Chen, Ping; 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 241 KB

The Discovery of N -((2 H -Tetrazol-5-yl

The Discovery of N -((2 H -Tetrazol-5-yl)methyl)-4-(( R )-1-((5 r ,8 R )-8-( tert -butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

✍ DeMong, Duane; Dai, Xing; Hwa, Joyce; Miller, Michael; Lin, Sue-Ing; Kang, Ling; 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 529 KB

Stereoselective Preparation of N -[( R,R

Stereoselective Preparation of N -[( R,R )-( E )-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl- N -methyl-3,5-bis(trifluoromethyl)benzamide, a Potent and Orally Active Dual Neurokinin NK 1 /NK 2 Receptor Antagonist

✍ Gerspacher, Marc; Lewis, Christine; Ball, Howard A.; Howes, Colin; Subramanian, 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 99 KB

Potent, Orally Bioavailable Calcitonin G

Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N -[(3 R ,6 S )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

✍ Paone, Daniel V.; Shaw, Anthony W.; Nguyen, Diem N.; Burgey, Christopher S.; Den 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 54 KB

Discovery of (1R,2R)-N-(4-(6-isopropylpy

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

✍ Hao, Junliang; Dehlinger, Veronique; Fivush, Adam M.; Rudyk, Helene C.E.; Britto 📂 Article 📅 2013 🏛 Elsevier Science 🌐 English ⚖ 452 KB

Discovery of a Potent, Selective, and Or

Discovery of a Potent, Selective, and Orally Bioavailable c-Met Inhibitor: 1-(2-Hydroxy-2-methylpropyl)- N -(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazole-4-carboxamide (AMG 458)

✍ Liu, Longbin; Siegmund, Aaron; Xi, Ning; Kaplan-Lefko, Paula; Rex, Karen; Chen, 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 191 KB