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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N -[(3 R ,6 S )-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1 H -imidazo[4,5- b ]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

✍ Scribed by Paone, Daniel V.; Shaw, Anthony W.; Nguyen, Diem N.; Burgey, Christopher S.; Deng, James Z.; Kane, Stefanie A.; Koblan, Kenneth S.; Salvatore, Christopher A.; Mosser, Scott D.; Johnston, Victor K.; Wong, Bradley K.; Miller-Stein, Cynthia M.; Hershey, James C.; Graham, Samuel L.; Vacca, Joseph P.; Williams, Theresa M.

Book ID: 118210232
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 54 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm070668p

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