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The clinical importance and prognostic implications of microsatellite instability in sporadic cancer

โœ Scribed by D.A Lawes; S SenGupta; P.B Boulos


Book ID
117818002
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
194 KB
Volume
29
Category
Article
ISSN
0748-7983

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## BACKGROUND. Microsatellite instability (MI) has been reported in some sporadic colon tumors and in cases of hereditary nonpolyposis colorectal cancer (HNPCC). The criteria for HNPCC have not been fully defined, and clinical criteria are used to identify as many HNPCC patients as possible. To cl

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## Abstract Microsatellite instability in sporadic colon cancer is associated with an improved prognosis. Recent studies, however, have suggested that microsatellite unstable cancers with mutations in the proapoptotic gene __BAX__ have a relatively poor prognosis, whereas those with mutations in tr