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Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications

✍ Scribed by Sinicrope, F. A.; Sargent, D. J.

Book ID
115466893
Publisher
American Association for Cancer Research
Year
2012
Tongue
English
Weight
726 KB
Volume
18
Category
Article
ISSN
1078-0432

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## Abstract Microsatellite instability in sporadic colon cancer is associated with an improved prognosis. Recent studies, however, have suggested that microsatellite unstable cancers with mutations in the proapoptotic gene __BAX__ have a relatively poor prognosis, whereas those with mutations in tr