The clinical value of microsatellite instability and a loss in heterozygosity in sporadic breast cancers
β Scribed by Hirotaka Iwase; Hiroji Iwata; Tatsuya Toyama; Yasuo Hara; Yoko Omoto; Yoshiaki Ando; Takaaki Nakamura; Shunzo Kobayashi
- Publisher
- Springer Japan
- Year
- 1997
- Tongue
- English
- Weight
- 419 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1340-6868
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Gastric cancers are rarely diagnosed before the age of 40 years and the incidence reaches a peak during the 7th decade in the general population. A molecular mechanism of early tumor onset may be determined by comparing microsatellite instability (MSI), indicative of error-prone mismatch repair, and
In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments RER+ tumors. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. Although the MSI phenotype is wel
## Abstract ## Background. Microsatellite instability (MSI) in head and neck squamous cell carcinoma (HNSCC) has been reported with a wide range of frequencies. The aim of our study was to disclose the frequency and basis of MSI in HNSCC and to correlate MSI and findings on loss of heterozygosity