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Analysis of Loss of heterozygosity and immunohistochemistry in BRCA1 gene in sporadic breast cancers

✍ Scribed by Kada Peela Bheeman Dinesh; Halagowder Devaraj; Vadivel Murugan; Ramamurthy Rajaraman; Sivasidhambaram Niranjali

Publisher
Springer
Year
2006
Tongue
English
Weight
178 KB
Volume
287
Category
Article
ISSN
0300-8177

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## Abstract Previous studies have shown that breast cancers have more aggressive pathologic features in young women. In order to examine genetic alterations associated with early‐onset breast cancer, 31 patients with no known family history, aged 26–35 years at diagnosis, were examined for loss of

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## Abstract Breast cancer occurs rarely in men and risk factors for the disease include germline mutations of the __BRCA2__ gene. High frequency of allelic loss at the __BRCA2__ locus has been reported in sporadic breast tumors, but somatic mutations of __BRCA2__ are very rare. Here we report the f