To date, several tumor-suppressor genes responsible for the tumorigenesis of colorectal cancer have been identified. However, studies of loss of heterozygosity (LOH) have suggested several chromosomal regions which may contain additional tumor-suppressor genes for colorectal cancer. To determine the
✦ LIBER ✦
Loss of heterozygosity atBRCA1/2loci in hereditary and sporadic ovarian cancers
✍ Scribed by I. Brożek; K. Ochman; J. Dębniak; L. Morzuch; M. Ratajska; M. Stepnowska; M. Stukan; J. Emerich; J. Limon
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 112 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1234-1983
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## Abstract Frequent loss of heterozygosity (LOH) on both arms of chromosome 17 has been described in ovarian carcinoma (OC) by a number of groups, and the recent fine mapping of an inherited breast‐ovarian cancer gene (__brc__Al) to a small region at 17q 12–21 has focused interest on this area. We
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