Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers
β Scribed by Luca Messerini; Monica Ciantelli; Silvana Baglioni; Annarita Palomba; Giancarlo Zampi; Laura Papi
- Book ID
- 117253650
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 664 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1532-8392
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The reproducibility of microsatellite instability from different regions of the same sporadic colon cancer has not been addressed. We therefore microdissected and extracted DNA from three to nine separate regions of 13 highly unstable sporadic colon cancers. Each region was then evaluated by polymer
A series of 44 sporadic mucinous colorectal carcinomas was analysed for microsatellite instability; 30 consecutive sporadic non-mucinous colorectal cancers served as controls. Mucinous carcinomas showed microsatellite instability more frequently than non-mucinous cancers: 26/44 and 8/30, respectivel