Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
✍ Scribed by Liu, Bo; Nicolaides, Nicholas C.; Markowitz, Sanford; Willson, James K.V.; Parsons, Ramon E.; Jen, Jin; Papadopolous, Nickolas; Peltomäki, Päivi; de la Chapelle, Albert; Hamilton, Stanley R.
- Book ID
- 109914927
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 872 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1061-4036
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Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with inherited mutation in one of four DNA mismatch repair genes. Somatic mutations in the same genes are also found in a subset of sporadic colorectal cancers. A defect in DNA mismatch repair results in an RER (replication e
## Abstract ## BACKGROUND hMLH1, the human MutL homologue, has been linked to microsatellite instability (MSI) in gastrointestinal tumors. However, to the authors' knowledge, the role of hMLH1, the other mismatch repair genes (MMR), and MSI in ovarian carcinoma has not been well defined. The purpo