✦ LIBER ✦

Clinical implications of microsatellite instability in colorectal cancers

✍ Scribed by Hiromi Muta; Masayuki Noguchi; Manuel Perucho; Kyousuke Ushio; Kenichi Sugihara; Atsushi Ochiai; Hajime Nawata; Setsuo Hirohashi

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 607 KB
Volume: 77
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960115)77:2<265::aid-cncr7>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Microsatellite instability (MI) has been reported in some sporadic colon tumors and in cases of hereditary nonpolyposis colorectal cancer (HNPCC). The criteria for HNPCC have not been fully defined, and clinical criteria are used to identify as many HNPCC patients as possible. To clarify the conformity of these criteria with the identification of eligible HNPCC cases, we analyzed MI in HNPCC patients diagnosed using clinical criteria.

METHODS.

Genomic DNA was extracted from surgical specimens of 56 colorectal cancers, including 36 from patients diagnosed with HNPCC using the clinical criteria. We analyzed four microsatellite loci using 3Wabeled primers.

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