The application of a thiohydroxamic acid (THA) linker in the solid-phase synthesis of a urea library
β Scribed by David M Whitehead; Toby Jackson; Stephen C McKeown; Anne Routledge
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 299 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1381-5148
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Abstrnctr A general method for the solid-phase synthesis of ureas has been developed. The key intermediate being a p-nitrophenylcarbamate which is transformed into the urea by reaction with primary or secondary amines. The products obtained are of high chemical purity. The generation of molecular d