𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A novel linker for the solid-phase synthesis of a library of 3′-thiophosphorylated dinucleotides

✍ Scribed by Arlène Roland; Yufang Xiao; Yi Jin; Radhakrishnan P Iyer

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
112 KB
Volume
42
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The preparation of a controlled-pore-glass (CPG) support carrying a novel linker is described. This support was compatible with the established phosphoramidite method of solid-phase oligonucleotide synthesis. The use of this linker for the synthesis of a library of 3%-thiophosphorylated dinucleotides is described.

📜 SIMILAR VOLUMES

Novel linker for the solid-phase synthes
Novel linker for the solid-phase synthesis of guanidines
✍ John A Josey; Catherine A Tarlton; Courtney E Payne 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 180 KB

A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 ° or 2 ° amine affords resin