Solid phase synthesis of urea libraries using a diversifiable thiophenoxy carbonyl linker
β Scribed by Bruce A Dressman; Upinder Singh; Stephen W Kaldor
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 255 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
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A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN 2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution.
A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-(N-piperazino)prop-l-enyl-l-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker for attachment of ketones that is compatible with ani
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