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Solid-phase synthesis of unsymmetrical ureas through the use of Kenner safety-catch linker

✍ Scribed by Daniela Fattori; Piero D'Andrea; Marina Porcelloni

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 150 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02656-4

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✦ Synopsis

A new strategy for the solid-phase synthesis of unsymmetrical ureas is described. Upon treatment of Kenner safety-catch linker with an isocyanate, followed by TMSCHN 2 or iodoacetonitrile and an amine, the corresponding unsymmetrical ureas are released in solution.

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