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Solid phase synthesis of 2-aminobutadienes using a piperazine linker

✍ Scribed by Nicholas W. Hird; Kazuyuki Irie; Katsunori Nagai

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
195 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-(N-piperazino)prop-l-enyl-l-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker for attachment of ketones that is compatible with anion chemistry.

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Solid phase synthesis of sulfonamides us
Solid phase synthesis of sulfonamides using a carbamate linker
✍ B. Raju; Timothy P. Kogan πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 298 KB

A method for the synthesis of sulfonamides on a solid support by immobilizing amines through the nitrogen atom using a carbamate linkage is described.