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A simple linker for the attachment of aldehydes to the solid phase. Application to solid phase synthesis by the multipin™ method

✍ Scribed by Nicholas J. Ede; Andrew M. Bray

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
226 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A simple linker has been developed for the attachment of ahtehyde fimctionality. The aldehyde substrate is condensed with a support-bound serine or threonine to give an oxazolidine. The oxazolidine linker is stable to the conditions of Fntoc peptide synthesis, inchtding TFA treatment, but is cleaved by mild aqueous acid at 60°C. The method is used, in conjunction u'ilh the Multipin method, to prepare a set of peptide ahlehydes.

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