Stable attachment of the HMB-linker to continuous cellulose membranes for parallel solid phase spot synthesis

A simple linker for the attachment of al

A simple linker for the attachment of aldehydes to the solid phase. Application to solid phase synthesis by the multipin™ method

✍ Nicholas J. Ede; Andrew M. Bray 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 226 KB

A simple linker has been developed for the attachment of ahtehyde fimctionality. The aldehyde substrate is condensed with a support-bound serine or threonine to give an oxazolidine. The oxazolidine linker is stable to the conditions of Fntoc peptide synthesis, inchtding TFA treatment, but is cleaved