✦ LIBER ✦

Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the Multipin™ support

✍ Scribed by Chinh T. Bui; Andrew M. Bray; Francesca Ercole; Yen Pham; Firas A. Rasoul; N.Joe Maeji

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 225 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00426-8

No coin nor oath required. For personal study only.

✦ Synopsis

A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.

📜 SIMILAR VOLUMES

Solid phase synthesis of C-terminal pept

Solid phase synthesis of C-terminal peptide amides: development of a new aminoethyl-polystyrene linker on the Multipin™ solid support

✍ Chinh T. Bui; Andrew M. Bray; Thao Nguyen; Francis Ercole; N. Joe Maeji 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 2 views

A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th

Novel α-hydroxyethyl-polystyrene, α-chlo

Novel α-hydroxyethyl-polystyrene, α-chloroethyl-polystyrene and α-amino-oxyethyl-polystyrene linkers on the multipin™ solid support for solid-phase organic synthesis

✍ Chinh T. Bui; N. Joe Maeji; Andrew M. Bray 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 78 KB 👁 1 views

A New Versatile Linker for the Solid-Pha

A New Versatile Linker for the Solid-Phase Synthesis of Secondary Amines.

✍ Heiko Glatz; Willi Bannwarth 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 148 KB 👁 1 views

Use of halomethyl resins to immobilize a

Use of halomethyl resins to immobilize amines: An efficient method for synthesis of sulfonamides and amides on a solid support

✍ B. Raju; Timothy P. Kogan 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 295 KB

Methods for the synthesis of chloromethyl and bromomethyl equivalents of Wang's resin are described. To explore the utility of this acid cleavable resin, amines were immobilized through the nitrogen atom, further functionalized, and then cleaved under acid conditions.

The development of solid phase protocols

The development of solid phase protocols for a backbone amide linker and its application to the Boc-based assembly of linear peptides

✍ Gregory T. Bourne; Wim D.F. Meutermans; Mark L. Smythe 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 235 KB

Efficient Solid Phase Synthesis of Cleav

Efficient Solid Phase Synthesis of Cleavable Oligodeoxynucleotides Based on a Novel Strategy for the Synthesis of 5′-S-(4,4′-Dimethoxytrityl)-2′-deoxy-5′-thionucleoside Phosphoramidites

✍ Kerstin Jahn-Hofmann; Joachim W. Engels 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 390 KB 👁 1 views

## Abstract The incorporation of a specific cleavage site into an oligodeoxynucleotide can be achieved by utilizing the four 5′‐__S__‐(4,4′‐dimethoxytrityl)‐2′‐deoxy‐5′‐thionucleoside 3′‐(2‐cyanoethyl diisopropylphosphoramidites) **5** and **15a**–**c** (__Fig. 1__). Based on the silver ion assiste