✦ LIBER ✦

Resin-bound thiophenols as SNAR-labile linkers: application to the solid phase synthesis of aminopyridazines

✍ Scribed by Isabelle Parrot; Camille-Georges Wermuth; Marcel Hibert

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 233 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01533-6

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✦ Synopsis

A versatile approach for the solid phase synthesis of aminopyridazines was developed. Commercially available or novel resin-bound thiophenols are used to link 3,6-dichloropyridazine to solid supports and to introduce diversity into the molecule by direct cleavage of nucleophilic amines without oxidation to sulfones.

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