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The 8p11 myeloproliferative syndrome owing to rare FGFR1OP2-FGFR1 fusion

✍ Scribed by Masahiro Onozawa; Kazumasa Ohmura; Makoto Ibata; Junko Iwasaki; Kohei Okada; Ikumi Kasahara; Keisuke Yamaguchi; Kanako Kubota; Shinichi Fujisawa; Akio Shigematsu; Tomoyuki Endo; Takeshi Kondo; Satoshi Hashino; Junji Tanaka; Yoshihiro Matsuno; Masahiro Asaka; Masahiro Imamura

Book ID
114794891
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
211 KB
Volume
86
Category
Article
ISSN
0902-4441

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Identification of a novel gene, FGFR1OP2
Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome
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## Abstract The 8p11 myeloproliferative syndrome (EMS) is an aggressive hematological malignancy caused by the fusion of diverse partner genes to fibroblast growth factor receptor 1 (__FGFR1__). The partner proteins promote dimerization and ligand‐independent activation of __FGFR1__‐encoded tyrosin

8p11 myeloproliferative syndrome with a
8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
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## Abstract 8p11 myeloproliferative syndrome (EMS) is a clinical‐pathologic entity characterized by rearrangements involving the __FGFR1__ gene, which encodes a receptor tyrosine kinase. These rearrangements invariably lead to aberrant fusion proteins in which the kinase activity is constitutively