## Abstract The 8p11 myeloproliferative syndrome (EMS) is an aggressive hematological malignancy caused by the fusion of diverse partner genes to fibroblast growth factor receptor 1 (__FGFR1__). The partner proteins promote dimerization and ligand‐independent activation of __FGFR1__‐encoded tyrosin
The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1
✍ Scribed by Walz, C; Chase, A; Schoch, C; Weisser, A; Schlegel, F; Hochhaus, A; Fuchs, R; Schmitt-Gräff, A; Hehlmann, R; Cross, N C P
- Book ID
- 110056234
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 254 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0887-6924
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## Abstract 8p11 myeloproliferative syndrome (EMS) is a clinical‐pathologic entity characterized by rearrangements involving the __FGFR1__ gene, which encodes a receptor tyrosine kinase. These rearrangements invariably lead to aberrant fusion proteins in which the kinase activity is constitutively
## Abstract We have investigated two patients with acquired chromosomal rearrangements, a male presenting with a t(1;9)(p34;q34) and B cell progenitor acute lymphoid leukemia and a female presenting with a t(8;12)(p11;q15) and the 8p11 myeloproliferative syndrome. We determined that the t(1;9) fuse