LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome
β Scribed by Soler, G; Nusbaum, S; Varet, B; Macintyre, E A; Vekemans, M; Romana, S P; Radford-Weiss, I
- Book ID
- 109887112
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 131 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0887-6924
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## Abstract The 8p11 myeloproliferative syndrome (EMS) is an aggressive hematological malignancy caused by the fusion of diverse partner genes to fibroblast growth factor receptor 1 (__FGFR1__). The partner proteins promote dimerization and ligandβindependent activation of __FGFR1__βencoded tyrosin
## Abstract 8p11 myeloproliferative syndrome (EMS) is a clinicalβpathologic entity characterized by rearrangements involving the __FGFR1__ gene, which encodes a receptor tyrosine kinase. These rearrangements invariably lead to aberrant fusion proteins in which the kinase activity is constitutively