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LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome

✍ Scribed by Soler, G; Nusbaum, S; Varet, B; Macintyre, E A; Vekemans, M; Romana, S P; Radford-Weiss, I


Book ID
109887112
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
131 KB
Volume
23
Category
Article
ISSN
0887-6924

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## Abstract The 8p11 myeloproliferative syndrome (EMS) is an aggressive hematological malignancy caused by the fusion of diverse partner genes to fibroblast growth factor receptor 1 (__FGFR1__). The partner proteins promote dimerization and ligand‐independent activation of __FGFR1__‐encoded tyrosin

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## Abstract 8p11 myeloproliferative syndrome (EMS) is a clinical‐pathologic entity characterized by rearrangements involving the __FGFR1__ gene, which encodes a receptor tyrosine kinase. These rearrangements invariably lead to aberrant fusion proteins in which the kinase activity is constitutively