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TEL/AML-1 fusion gene: its frequency and prognostic significance in childhood acute lymphoblastic leukemia

✍ Scribed by Altaf Jamil; Karl S Theil; Samir Kahwash; Frederick B Ruymann; Kathryn J Klopfenstein

Book ID
114134924
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
369 KB
Volume
122
Category
Article
ISSN
0165-4608

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## Abstract The __TEL/AML1__ rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined __TEL/AML1__ using nested reverse‐transcription polymerase chain reaction (RT‐PCR) and correlated __TEL/AML1__ with cytogenetics and i

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence