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1144 Risk Factors for TEL-AML Fusion Gene and Childhood Acute Lymphoblastic Leukemia in Egypt

โœ Scribed by Ezzat, S.; Rashed, W.; Salem, S.; El-Daly, M.; Abdel-Hamid, M.; El-Haddad, A.; Sedhom, I.; Loffredo, C.; Amr, S.


Book ID
122499485
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
56 KB
Volume
48
Category
Article
ISSN
0959-8049

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence