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Characterization of additional genetic events in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion: a molecular cytogenetics study

โœ Scribed by Ma, S K; Wan, T S K; Cheuk, A T C; Fung, L F; Chan, G C F; Chan, S Y; Ha, S Y; Chan, L C


Book ID
110054964
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
571 KB
Volume
15
Category
Article
ISSN
0887-6924

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence