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TEL/AML1 Fusion Gene in Childhood Acute Lymphoblastic Leukemia in Southern Taiwan

✍ Scribed by Pei-Chin Lin; Tai-Tsung Chang; Shiu-Ru Lin; Shyh-Shin Chiou; Ren-Chin Jang; Jiunn-Ming Sheen


Book ID
118649009
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
434 KB
Volume
24
Category
Article
ISSN
0257-5655

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence