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Prevalence of TEL/AML1 fusion gene in Brazilian pediatric patients with acute lymphoblastic leukemia

โœ Scribed by P.R.G. Zen; M.C. Lima; V.M. Coser; L. Silla; L. Daudt; M.S. Fernandes; J. Neumann; M.S. Mattevi; R. Ortigara; G.A. Paskulin


Book ID
113512327
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
171 KB
Volume
151
Category
Article
ISSN
0165-4608

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence