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TEL–AML1 fusion gene frequency in paediatric acute lymphoblastic leukaemia in Brazil

✍ Scribed by I. Q. Magalhães; M. S. Pombo-de-Oliveira; C. A. Bennett; J. C. Cordoba; J. Dobbin; A. M. Ford; M. F. Greaves

Book ID
108672323
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
113 KB
Volume
111
Category
Article
ISSN
0007-1048

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✍ Ivan F. Loncarevic; Barbara Roitzheim; Jutta Ritterbach; Susanne Viehmann; Arndt 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 2 views

TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence