Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. The peak incidence of ALL between ages 2 and 5 is accounted for by one subtype, referred to as common acute lymphoblastic leukemia (cALL). About 25% of cALL patients have the TEL-AML1 gene fusion derived from the t(12;21
Characteristics of TEL/AML-1 positive acute lymphoblastic leukemia in Hungarian children
✍ Scribed by Pajor, László ;Lacza, Ágnes ;Jáksó, Pál ;Kajtár, Béla
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 66 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0098-1532
- DOI
- 10.1002/mpo.1220
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## Abstract The __TEL/AML1__ rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined __TEL/AML1__ using nested reverse‐transcription polymerase chain reaction (RT‐PCR) and correlated __TEL/AML1__ with cytogenetics and i
TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence
## Abstract ## BACKGROUND The translocation t(12;21)(p13;q22), which produces the TEL/AML1 fusion gene, is the most frequent chromosomal abnormality in patients with childhood acute lymphoblastic leukemia (ALL) and generally is associated with a favorable prognosis. Furthermore, real‐time quantita