Significance of the TEL-AML1 fusion gene in childhood AML
β Scribed by Rubnitz, JE; Downing, JR; Pui, C-H
- Book ID
- 110054303
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 64 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0887-6924
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## Abstract The __TEL/AML1__ rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined __TEL/AML1__ using nested reverseβtranscription polymerase chain reaction (RTβPCR) and correlated __TEL/AML1__ with cytogenetics and i
TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence