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Significance of the TEL-AML1 fusion gene in childhood AML

✍ Scribed by Rubnitz, JE; Downing, JR; Pui, C-H


Book ID
110054303
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
64 KB
Volume
13
Category
Article
ISSN
0887-6924

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## Abstract The __TEL/AML1__ rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined __TEL/AML1__ using nested reverse‐transcription polymerase chain reaction (RT‐PCR) and correlated __TEL/AML1__ with cytogenetics and i

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TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a consequence of the cryptic chromosomal translocation t(12;21)(p13;q22). In a cohort of 50 RT-PCR-positive TEL/AML1 patients, karyotype examination by GTG banding and fluorescence