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Targeting histone deacetylases: development of vorinostat for the treatment of cancer

✍ Scribed by Richon, Victoria M


Book ID
121016973
Publisher
Future Medicine
Year
2010
Tongue
English
Weight
956 KB
Volume
2
Category
Article
ISSN
1750-1911

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## Abstract Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of nonhistone transcription regulatory proteins, thus modulating the expression of genes important for complex biological events. Dysregulation of HDACs and aberrant chromatin acetylation and deacetylatio