✦ LIBER ✦

Histone Deacetylase Inhibitors: Development of Suberoylanilide Hydroxamic Acid (SAHA) for the Treatment of Cancers

✍ Scribed by Victoria M. Richon; Xianbo Zhou; Richard A. Rifkind; Paul A. Marks

Book ID: 115590107
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 39 KB
Volume: 27
Category: Article
ISSN: 1079-9796
DOI: 10.1006/bcmd.2000.0376

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Histone deacetylase inhibitor, suberoyla

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

✍ Takashi Kumagai; Naoki Wakimoto; Dong Yin; Sigal Gery; Norihiko Kawamata; Noriyu 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 461 KB 👁 1 views

## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th

A phase I clinical trial of an oral form

A phase I clinical trial of an oral formulation of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)

📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 139 KB

In vitro and in vivo histone deacetylase

In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer

✍ Amy L. Cooper; Victoria L. Greenberg; Pamela S. Lancaster; John R. van Nagell Jr 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 168 KB

In vivo redox state of Human thioredoxin

In vivo redox state of Human thioredoxin and redox shift by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)

✍ J. Ungerstedt; Y. Du; H. Zhang; D. Nair; A. Holmgren 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 622 KB

Sequence-specific potentiation of topois

Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid

✍ Douglas C. Marchion; Elona Bicaku; Adil I. Daud; Victoria Richon; Daniel M. Sull 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 469 KB 👁 1 views

## Abstract Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single age

Cancer biology: mechanism of antitumour

Cancer biology: mechanism of antitumour action of vorinostat (suberoylanilide hydroxamic acid), a novel histone deacetylase inhibitor

✍ Richon, V M 📂 Article 📅 2006 🏛 Nature Publishing Group 🌐 English ⚖ 149 KB