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A phase I clinical trial of an oral formulation of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)


Book ID
117659629
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
139 KB
Volume
38
Category
Article
ISSN
0959-8049

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Histone deacetylase inhibitor, suberoyla
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## Abstract Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In th